Long-term follow-up of severe respiratory distress syndrome treated with IPPB

James R. Harrod; Philippe L'Heureux; O. Douglas Wangensteen; Carl E. Hunt

doi:10.1016/S0022-3476(74)80623-2

Long-term follow-up of severe respiratory distress syndrome treated with IPPB

James R. Harrod, Philippe L'Heureux, O. Douglas Wangensteen, Carl E. Hunt

Pulmonary, Allergy, Critical Care and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

A detailed evaluation is presented of the developmental and cardiopulmonary status at one to five years of age in 22 unselected survivors of severe RDS and IPPB, 15 of whom were considered to have BPD. Fifteen patients (68 per cent) were developmentally "indistinguishable from normal," six (27 per cent) were "suspect," and only one patient had definite developmental impairment. Fifteen of the 22 patients (68 per cent) had persistently abnormal thoracic roentgenograms, with varying degrees of interstitial infiltrates and hyperexpansion. The persistence of abnormal roentgenographic findings was significantly related to duration of ambient O₂ therapy; an additional relationship to duration of intubation could not be excluded. Of the 16 patients now over two years of age, eight (50 per cent) have persistent right ventricular hypertrophy, 10 (62.5 per cent) have arterial hypoxemia, and 15 (94 per cent) have AaD_O₂ values breathing 100 per cent O₂ of greater than 100 mm. Hg. Considering the severity of the initial RDS, however, it is significant that 20 of the 22 patients (91 per cent) have no apparent residual cardiopulmonary symptomatology.

Original language	English (US)
Pages (from-to)	277-286
Number of pages	10
Journal	The Journal of pediatrics
Volume	84
Issue number	2
DOIs	https://doi.org/10.1016/S0022-3476(74)80623-2
State	Published - Feb 1974

Bibliographical note

Funding Information:
From the Departments of Pediatrics, Radiology, and Physiology, University of Minnesota Hospitals and Medical School. Supported in part by Public Health Service Grant No. HD0053-12, the Cardiovascular Clinical Research Program Project No. 115, and the Dwan Family Fund. Presented in part at Midwest Pediatric Research Society, Chicago, Ill. November, 1972. *Reprint address: Department of Pediatrics, Box 92 Mayo, University o/'Minnesota Hospitals, Minneapolis, Minn. 5545L

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title = "Long-term follow-up of severe respiratory distress syndrome treated with IPPB",

abstract = "A detailed evaluation is presented of the developmental and cardiopulmonary status at one to five years of age in 22 unselected survivors of severe RDS and IPPB, 15 of whom were considered to have BPD. Fifteen patients (68 per cent) were developmentally {"}indistinguishable from normal,{"} six (27 per cent) were {"}suspect,{"} and only one patient had definite developmental impairment. Fifteen of the 22 patients (68 per cent) had persistently abnormal thoracic roentgenograms, with varying degrees of interstitial infiltrates and hyperexpansion. The persistence of abnormal roentgenographic findings was significantly related to duration of ambient O2 therapy; an additional relationship to duration of intubation could not be excluded. Of the 16 patients now over two years of age, eight (50 per cent) have persistent right ventricular hypertrophy, 10 (62.5 per cent) have arterial hypoxemia, and 15 (94 per cent) have AaDO2 values breathing 100 per cent O2 of greater than 100 mm. Hg. Considering the severity of the initial RDS, however, it is significant that 20 of the 22 patients (91 per cent) have no apparent residual cardiopulmonary symptomatology.",

author = "Harrod, {James R.} and Philippe L'Heureux and Wangensteen, {O. Douglas} and Hunt, {Carl E.}",

note = "Funding Information: From the Departments of Pediatrics, Radiology, and Physiology, University of Minnesota Hospitals and Medical School. Supported in part by Public Health Service Grant No. HD0053-12, the Cardiovascular Clinical Research Program Project No. 115, and the Dwan Family Fund. Presented in part at Midwest Pediatric Research Society, Chicago, Ill. November, 1972. *Reprint address: Department of Pediatrics, Box 92 Mayo, University o/'Minnesota Hospitals, Minneapolis, Minn. 5545L",

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N1 - Funding Information: From the Departments of Pediatrics, Radiology, and Physiology, University of Minnesota Hospitals and Medical School. Supported in part by Public Health Service Grant No. HD0053-12, the Cardiovascular Clinical Research Program Project No. 115, and the Dwan Family Fund. Presented in part at Midwest Pediatric Research Society, Chicago, Ill. November, 1972. *Reprint address: Department of Pediatrics, Box 92 Mayo, University o/'Minnesota Hospitals, Minneapolis, Minn. 5545L

PY - 1974/2

Y1 - 1974/2

N2 - A detailed evaluation is presented of the developmental and cardiopulmonary status at one to five years of age in 22 unselected survivors of severe RDS and IPPB, 15 of whom were considered to have BPD. Fifteen patients (68 per cent) were developmentally "indistinguishable from normal," six (27 per cent) were "suspect," and only one patient had definite developmental impairment. Fifteen of the 22 patients (68 per cent) had persistently abnormal thoracic roentgenograms, with varying degrees of interstitial infiltrates and hyperexpansion. The persistence of abnormal roentgenographic findings was significantly related to duration of ambient O2 therapy; an additional relationship to duration of intubation could not be excluded. Of the 16 patients now over two years of age, eight (50 per cent) have persistent right ventricular hypertrophy, 10 (62.5 per cent) have arterial hypoxemia, and 15 (94 per cent) have AaDO2 values breathing 100 per cent O2 of greater than 100 mm. Hg. Considering the severity of the initial RDS, however, it is significant that 20 of the 22 patients (91 per cent) have no apparent residual cardiopulmonary symptomatology.

AB - A detailed evaluation is presented of the developmental and cardiopulmonary status at one to five years of age in 22 unselected survivors of severe RDS and IPPB, 15 of whom were considered to have BPD. Fifteen patients (68 per cent) were developmentally "indistinguishable from normal," six (27 per cent) were "suspect," and only one patient had definite developmental impairment. Fifteen of the 22 patients (68 per cent) had persistently abnormal thoracic roentgenograms, with varying degrees of interstitial infiltrates and hyperexpansion. The persistence of abnormal roentgenographic findings was significantly related to duration of ambient O2 therapy; an additional relationship to duration of intubation could not be excluded. Of the 16 patients now over two years of age, eight (50 per cent) have persistent right ventricular hypertrophy, 10 (62.5 per cent) have arterial hypoxemia, and 15 (94 per cent) have AaDO2 values breathing 100 per cent O2 of greater than 100 mm. Hg. Considering the severity of the initial RDS, however, it is significant that 20 of the 22 patients (91 per cent) have no apparent residual cardiopulmonary symptomatology.

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Long-term follow-up of severe respiratory distress syndrome treated with IPPB

Abstract

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