Abstract
We have investigated the effects of chronic oral administration of two anorectic substances, fenfluramine and aminorex, especially on the pulmonary circulation in young pigs with one ligated pulmonary artery. The pulmonary vascular reactivity was tested by alveolar hypoxia, alveolar hyperoxia and infusion of prostaglandin F2α No elevation of pulmonary arterial pressures or resistance were found due to the intake of fenfluramine or aminorex over a three month period. The responses to the vasoconstrictor stimuli, hypoxia and prostaglandin F2α, and to the vasodilator stimulus, hyperoxia, were equal and not augmented in the drug groups. Fenfluramine or aminorex could therefore not be shown to have an adverse effect on the pulmonary circulation or on the reactivity of the pulmonary vascular bed in the pig, but fenfluramine elevated systemic arterial pressure.
Original language | English (US) |
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Pages (from-to) | 313-320 |
Number of pages | 8 |
Journal | Basic research in cardiology |
Volume | 74 |
Issue number | 3 |
DOIs | |
State | Published - May 1979 |
Externally published | Yes |