Long-term Cognitive Trajectories and Mortality in Older Women

Kristine Yaffe, Carrie B. Peltz, Susan K. Ewing, Charles E. McCulloch, Steve R. Cummings, Jane A. Cauley, Teresa A. Hillier, Kristine E. Ensrud

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background: Few studies have examined whether change in cognition is linked to mortality. This study examined the relationship between cognitive trajectories in older age and risk of death. Methods: We studied community-dwelling, nondemented women aged 65+ (mean age = 71) enrolled in a prospective study of aging and followed up to 25 years. A modified Mini-Mental State Examination (mMMSE) and Trail Making Task Part B (TMTB) were administered at multiple visits during follow-up. We examined the association between cognitive trajectories (analyzed by quintiles) from baseline to age 80 (n = 7,477 for mMMSE and n = 6,503 for TMTB) and all-cause mortality after age 80 using Cox regression models, both unadjusted and adjusted for education, physical activity, alcohol, depression score, current smoking and history of hypertension and diabetes. Cause of death was determined from death certificates, classified as cardiovascular, cancer and other. Results: Women with greater rate of decline were older, less educated, less physically active, had higher depression score and were more likely to have a history of hypertension and diabetes (all p <. 01). Participants with the greatest decline (quintile 1) had an increased risk of death (mMMSE hazard ratio [HR] = 1.28; TMTB HR = 1.43] and those with the least decline (quintile 5) had a decreased risk of death (mMMSE HR = 0.73; TMTB HR = 0.61) compared with intermediate decliners (quintiles 2-4). Cognitive trajectories were associated with cardiovascular mortality and other causes of death, but not cancer deaths. Conclusions: Our study suggests that greater decline in general cognition or executive function is associated with higher rates of mortality in oldest-old women.

Original languageEnglish (US)
Pages (from-to)1074-1080
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume71
Issue number8
DOIs
StatePublished - Aug 1 2016

Bibliographical note

Funding Information:
The Study of Osteoporotic Fractures is supported by National Institutes of Health funding. The National Institute on Aging provides support under the following grant numbers: R01 AG005407, R01 AR35582, R01 AR35583, R01 AR35584, R01 AG005394, R01 AG027574, and R01 AG027576.

Keywords

  • All-cause mortality
  • Cardiovascular mortality
  • Cognitive trajectories
  • Executive function
  • Global cognition
  • Oldest old

Fingerprint Dive into the research topics of 'Long-term Cognitive Trajectories and Mortality in Older Women'. Together they form a unique fingerprint.

Cite this