Long-term brain and behavioral consequences of early-life iron deficiency

Bruce C. Kennedy, Diana J. Wallin, Phu V Tran, Michael K Georgieff

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Early-life iron deficiency anemia affects 30-50 % of pregnancies worldwide and causes deficits in cognitive development as well as socio-emotional abnormalities. More concerning, these deficits persist into adulthood, including increased risks of schizophrenia and depression, despite prompt iron repletion during childhood. Emerging evidence implicates long-term changes in the neural metabolome, proteome, and genome as potential biological bases underlying these effects. In turn, better knowledge of the underlying biology will lead to new methods of identifying young children at risk for brain iron deficiency and adjunct or rescue therapies designed to optimize their outcomes.

Original languageEnglish (US)
Title of host publicationFetal Development
Subtitle of host publicationResearch on Brain and Behavior, Environmental Influences, and Emerging Technologies
PublisherSpringer International Publishing
Pages295-316
Number of pages22
ISBN (Electronic)9783319220239
ISBN (Print)9783319220222
DOIs
StatePublished - Jan 1 2016

Keywords

  • Cognition
  • Developmental origins
  • Dopamine
  • Epigenetics
  • Fetus
  • Genomics
  • Infant
  • Iron
  • Proteomics

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  • Cite this

    Kennedy, B. C., Wallin, D. J., Tran, P. V., & Georgieff, M. K. (2016). Long-term brain and behavioral consequences of early-life iron deficiency. In Fetal Development: Research on Brain and Behavior, Environmental Influences, and Emerging Technologies (pp. 295-316). Springer International Publishing. https://doi.org/10.1007/978-3-319-22023-9_15