Long-term brain and behavioral consequences of early-life iron deficiency

Bruce Kennedy; Diana J. Wallin; Phu V. Tran; Michael K. Georgieff

doi:10.1007/978-3-319-22023-9_15

Long-term brain and behavioral consequences of early-life iron deficiency

Bruce Kennedy, Diana J. Wallin, Phu V. Tran, Michael K. Georgieff

Research output: Chapter in Book/Report/Conference proceeding › Chapter

10 Scopus citations

Abstract

Early-life iron deficiency anemia affects 30-50 % of pregnancies worldwide and causes deficits in cognitive development as well as socio-emotional abnormalities. More concerning, these deficits persist into adulthood, including increased risks of schizophrenia and depression, despite prompt iron repletion during childhood. Emerging evidence implicates long-term changes in the neural metabolome, proteome, and genome as potential biological bases underlying these effects. In turn, better knowledge of the underlying biology will lead to new methods of identifying young children at risk for brain iron deficiency and adjunct or rescue therapies designed to optimize their outcomes.

Original language	English (US)
Title of host publication	Fetal Development
Subtitle of host publication	Research on Brain and Behavior, Environmental Influences, and Emerging Technologies
Publisher	Springer International Publishing
Pages	295-316
Number of pages	22
ISBN (Electronic)	9783319220239
ISBN (Print)	9783319220222
DOIs	https://doi.org/10.1007/978-3-319-22023-9_15
State	Published - Jan 1 2016

Bibliographical note

Publisher Copyright:
© Springer International Publishing Switzerland 2016.

Keywords

Cognition
Developmental origins
Dopamine
Epigenetics
Fetus
Genomics
Infant
Iron
Proteomics

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10.1007/978-3-319-22023-9_15

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AU - Wallin, Diana J.

AU - Tran, Phu V.

AU - Georgieff, Michael K.

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AB - Early-life iron deficiency anemia affects 30-50 % of pregnancies worldwide and causes deficits in cognitive development as well as socio-emotional abnormalities. More concerning, these deficits persist into adulthood, including increased risks of schizophrenia and depression, despite prompt iron repletion during childhood. Emerging evidence implicates long-term changes in the neural metabolome, proteome, and genome as potential biological bases underlying these effects. In turn, better knowledge of the underlying biology will lead to new methods of identifying young children at risk for brain iron deficiency and adjunct or rescue therapies designed to optimize their outcomes.

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KW - Dopamine

KW - Epigenetics

KW - Fetus

KW - Genomics

KW - Infant

KW - Iron

KW - Proteomics

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ER -

Long-term brain and behavioral consequences of early-life iron deficiency

Abstract

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Keywords

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