Long-term antidepressant treatment: Alterations in cerebral capillary permeability

Sheldon H. Preskorn, Boyd K. Hartman, H. Brent Clark

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Chronic treatment of rats with amitriptyline (AMI) induced a persistent increase in the diffusibility of water into the brain (EW). This effect was observable 12 h after the last dose. AMI induces this alteration at plasma drug concentrations of 71±13 ng/ml (the therapeutic range for man is 100-250 ng/ml). Furthermore, chronic treatment potentiated the increase observed after acute drug administration and resulted in a 350% enhancement in the permeability of water across the cerebral capillary. Thus, long-term antidepressant administration can chronically influence cerebral function by affecting capillary permeability.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
Issue number1
StatePublished - Sep 1980
Externally publishedYes


  • Amitriptyline
  • Antidepressant
  • Blood-Brain barrier
  • Cerebral capillary
  • Chronic treatment
  • Extraction fraction
  • Permeability
  • Plasma drug concentration


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