Long-term antidepressant treatment: Alterations in cerebral capillary permeability

Sheldon H. Preskorn; Boyd K. Hartman; H. Brent Clark

doi:10.1007/BF00432362

Long-term antidepressant treatment: Alterations in cerebral capillary permeability

Sheldon H. Preskorn, Boyd K. Hartman, H. Brent Clark

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Abstract

Chronic treatment of rats with amitriptyline (AMI) induced a persistent increase in the diffusibility of water into the brain (E_W). This effect was observable 12 h after the last dose. AMI induces this alteration at plasma drug concentrations of 71±13 ng/ml (the therapeutic range for man is 100-250 ng/ml). Furthermore, chronic treatment potentiated the increase observed after acute drug administration and resulted in a 350% enhancement in the permeability of water across the cerebral capillary. Thus, long-term antidepressant administration can chronically influence cerebral function by affecting capillary permeability.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Psychopharmacology
Volume	70
Issue number	1
DOIs	https://doi.org/10.1007/BF00432362
State	Published - Sep 1980

Keywords

Amitriptyline
Antidepressant
Blood-Brain barrier
Cerebral capillary
Chronic treatment
Extraction fraction
Permeability
Plasma drug concentration

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10.1007/BF00432362

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abstract = "Chronic treatment of rats with amitriptyline (AMI) induced a persistent increase in the diffusibility of water into the brain (EW). This effect was observable 12 h after the last dose. AMI induces this alteration at plasma drug concentrations of 71±13 ng/ml (the therapeutic range for man is 100-250 ng/ml). Furthermore, chronic treatment potentiated the increase observed after acute drug administration and resulted in a 350% enhancement in the permeability of water across the cerebral capillary. Thus, long-term antidepressant administration can chronically influence cerebral function by affecting capillary permeability.",

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AU - Hartman, Boyd K.

AU - Clark, H. Brent

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N2 - Chronic treatment of rats with amitriptyline (AMI) induced a persistent increase in the diffusibility of water into the brain (EW). This effect was observable 12 h after the last dose. AMI induces this alteration at plasma drug concentrations of 71±13 ng/ml (the therapeutic range for man is 100-250 ng/ml). Furthermore, chronic treatment potentiated the increase observed after acute drug administration and resulted in a 350% enhancement in the permeability of water across the cerebral capillary. Thus, long-term antidepressant administration can chronically influence cerebral function by affecting capillary permeability.

AB - Chronic treatment of rats with amitriptyline (AMI) induced a persistent increase in the diffusibility of water into the brain (EW). This effect was observable 12 h after the last dose. AMI induces this alteration at plasma drug concentrations of 71±13 ng/ml (the therapeutic range for man is 100-250 ng/ml). Furthermore, chronic treatment potentiated the increase observed after acute drug administration and resulted in a 350% enhancement in the permeability of water across the cerebral capillary. Thus, long-term antidepressant administration can chronically influence cerebral function by affecting capillary permeability.

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KW - Antidepressant

KW - Blood-Brain barrier

KW - Cerebral capillary

KW - Chronic treatment

KW - Extraction fraction

KW - Permeability

KW - Plasma drug concentration

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Long-term antidepressant treatment: Alterations in cerebral capillary permeability

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