Abstract
The relative magnitudes of the chemical shift differences (δσs) in the two diastereomers of menthyl esters of known chiral derivatizing agents (CDAs) were compared to those of the α-methoxy-α-trifluoromethyl-1- naphthylacetyl (MTN(1)A) analogues I. Discrimination of the terminal diastereotopic methyl resonances in esters of the homologous, symmetrical carbinols II was evaluated. Remarkably, the methyls differed in the MTN (1)A esters III even when n = 15; an unexpected crossover in the sign of the δσ values was also observed.
Original language | English (US) |
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Pages (from-to) | 1768-1771 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 12 |
Issue number | 8 |
DOIs | |
State | Published - Apr 16 2010 |