Locoregional approaches to colorectal liver metastasis – intra-arterial

David G. Brauer, Michael I. D'Angelica

Research output: Chapter in Book/Report/Conference proceedingChapter


Locoregional therapies play a significant role in the management of patients with colorectal liver metastases due to the high rate of unresectable disease in these patients. Intra-arterial therapies defines a category of locoregional liver therapies that take advantage of the arterial-predominant perfusion of colorectal liver metastases to treat lesions, with the goal of converting patients to resectable disease or palliating disease. Intra-arterial therapies include embolization, chemoembolization, radioembolization, and hepatic artery infusion chemotherapy. Here we review the techniques, indications, and data supporting each of these approaches. In brief, embolic therapies have little if any significant data supporting their effectiveness in colorectal liver metastases but hepatic artery infusion chemotherapy has demonstrated treatment response in several different clinical scenarios and is increasingly being implemented and studied.

Original languageEnglish (US)
Title of host publicationContemporary Management of Metastatic Colorectal Cancer
Subtitle of host publicationA Precision Medicine Approach
Number of pages20
ISBN (Electronic)9780323917063
ISBN (Print)9780323985680
StatePublished - Jan 1 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.


  • Adjuvant therapy
  • Arterially directed therapy
  • Bland embolization
  • Colorectal liver metastases
  • Conversion to resectable disease
  • Embolization
  • Hepatic artery infusion
  • Hepatic artery infusion chemotherapy
  • Hepatic artery infusion pump
  • Liver directed therapy
  • Local therapy
  • Radioembolization
  • Regional therapy
  • Transarterial chemoembolization
  • Unresectable disease


Dive into the research topics of 'Locoregional approaches to colorectal liver metastasis – intra-arterial'. Together they form a unique fingerprint.

Cite this