Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

Juliane Junesch, Gustav Emilsson, Kunli Xiong, Shailabh Kumar, Takumi Sannomiya, Hudson Pace, Janos Vörös, Sang Hyun Oh, Marta Bally, Andreas B. Dahlin

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.

Original languageEnglish (US)
Pages (from-to)15080-15085
Number of pages6
JournalNanoscale
Volume7
Issue number37
DOIs
StatePublished - Oct 7 2015

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    Junesch, J., Emilsson, G., Xiong, K., Kumar, S., Sannomiya, T., Pace, H., Vörös, J., Oh, S. H., Bally, M., & Dahlin, A. B. (2015). Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature. Nanoscale, 7(37), 15080-15085. https://doi.org/10.1039/c5nr04208a