Localized 1H NMR spectroscopy in different regions of human brain in vivo at 7T: T 2 relaxation times and concentrations of cerebral metabolites

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Abstract

At the high field strength of 7T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures other than the occipital lobe. The purpose of the present study was to obtain high-quality spectra from various brain regions at 7T and to quantify the concentrations of different metabolites. To obtain concentrations of metabolites within four different regions of the brain, such as the occipital lobe, motor cortex, basal ganglia and cerebellum, the T 2 relaxation times of the singlets and J-coupled metabolites in these regions were measured for the first time at 7T. Our results demonstrate that high-quality, quantifiable spectra can be obtained in regions other than the occipital lobe at 7T utilizing a 16-channel transceiver coil and B 1 + shimming.

Original languageEnglish (US)
Pages (from-to)332-339
Number of pages8
JournalNMR in Biomedicine
Volume25
Issue number2
DOIs
StatePublished - Feb 1 2012

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Occipital Lobe
Metabolites
Relaxation time
Nuclear magnetic resonance spectroscopy
Brain
Magnetic Resonance Spectroscopy
Motor Cortex
Brain Diseases
Basal Ganglia
Cerebellum
Transceivers
Proton Magnetic Resonance Spectroscopy

Keywords

  • Basal ganglia
  • Cerebellum
  • LCModel
  • Motor cortex
  • Occipital lobe

Cite this

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title = "Localized 1H NMR spectroscopy in different regions of human brain in vivo at 7T: T 2 relaxation times and concentrations of cerebral metabolites",
abstract = "At the high field strength of 7T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures other than the occipital lobe. The purpose of the present study was to obtain high-quality spectra from various brain regions at 7T and to quantify the concentrations of different metabolites. To obtain concentrations of metabolites within four different regions of the brain, such as the occipital lobe, motor cortex, basal ganglia and cerebellum, the T 2 relaxation times of the singlets and J-coupled metabolites in these regions were measured for the first time at 7T. Our results demonstrate that high-quality, quantifiable spectra can be obtained in regions other than the occipital lobe at 7T utilizing a 16-channel transceiver coil and B 1 + shimming.",
keywords = "Basal ganglia, Cerebellum, LCModel, Motor cortex, Occipital lobe",
author = "Malgorzata Marjanska and Auerbach, {Edward J} and Romain Valabr{\`e}gue and {Van de Moortele}, Pierre-Francois and Gregor Adriany and Michael Garwood",
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T1 - Localized 1H NMR spectroscopy in different regions of human brain in vivo at 7T

T2 - T 2 relaxation times and concentrations of cerebral metabolites

AU - Marjanska, Malgorzata

AU - Auerbach, Edward J

AU - Valabrègue, Romain

AU - Van de Moortele, Pierre-Francois

AU - Adriany, Gregor

AU - Garwood, Michael

PY - 2012/2/1

Y1 - 2012/2/1

N2 - At the high field strength of 7T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures other than the occipital lobe. The purpose of the present study was to obtain high-quality spectra from various brain regions at 7T and to quantify the concentrations of different metabolites. To obtain concentrations of metabolites within four different regions of the brain, such as the occipital lobe, motor cortex, basal ganglia and cerebellum, the T 2 relaxation times of the singlets and J-coupled metabolites in these regions were measured for the first time at 7T. Our results demonstrate that high-quality, quantifiable spectra can be obtained in regions other than the occipital lobe at 7T utilizing a 16-channel transceiver coil and B 1 + shimming.

AB - At the high field strength of 7T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures other than the occipital lobe. The purpose of the present study was to obtain high-quality spectra from various brain regions at 7T and to quantify the concentrations of different metabolites. To obtain concentrations of metabolites within four different regions of the brain, such as the occipital lobe, motor cortex, basal ganglia and cerebellum, the T 2 relaxation times of the singlets and J-coupled metabolites in these regions were measured for the first time at 7T. Our results demonstrate that high-quality, quantifiable spectra can be obtained in regions other than the occipital lobe at 7T utilizing a 16-channel transceiver coil and B 1 + shimming.

KW - Basal ganglia

KW - Cerebellum

KW - LCModel

KW - Motor cortex

KW - Occipital lobe

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