Localized 1H NMR spectroscopy in different regions of human brain in vivo at 7T: T 2 relaxation times and concentrations of cerebral metabolites

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Abstract

At the high field strength of 7T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures other than the occipital lobe. The purpose of the present study was to obtain high-quality spectra from various brain regions at 7T and to quantify the concentrations of different metabolites. To obtain concentrations of metabolites within four different regions of the brain, such as the occipital lobe, motor cortex, basal ganglia and cerebellum, the T 2 relaxation times of the singlets and J-coupled metabolites in these regions were measured for the first time at 7T. Our results demonstrate that high-quality, quantifiable spectra can be obtained in regions other than the occipital lobe at 7T utilizing a 16-channel transceiver coil and B 1 + shimming.

Original languageEnglish (US)
Pages (from-to)332-339
Number of pages8
JournalNMR in biomedicine
Volume25
Issue number2
DOIs
StatePublished - Feb 2012

Keywords

  • Basal ganglia
  • Cerebellum
  • LCModel
  • Motor cortex
  • Occipital lobe

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