Abstract
At the high field strength of 7T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures other than the occipital lobe. The purpose of the present study was to obtain high-quality spectra from various brain regions at 7T and to quantify the concentrations of different metabolites. To obtain concentrations of metabolites within four different regions of the brain, such as the occipital lobe, motor cortex, basal ganglia and cerebellum, the T 2 relaxation times of the singlets and J-coupled metabolites in these regions were measured for the first time at 7T. Our results demonstrate that high-quality, quantifiable spectra can be obtained in regions other than the occipital lobe at 7T utilizing a 16-channel transceiver coil and B 1 + shimming.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 332-339 |
| Number of pages | 8 |
| Journal | NMR in Biomedicine |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2012 |
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Keywords
- Basal ganglia
- Cerebellum
- LCModel
- Motor cortex
- Occipital lobe
Cite this
Localized 1H NMR spectroscopy in different regions of human brain in vivo at 7T : T 2 relaxation times and concentrations of cerebral metabolites. / Marjanska, Malgorzata; Auerbach, Edward J; Valabrègue, Romain; Van de Moortele, Pierre-Francois; Adriany, Gregor; Garwood, Michael.
In: NMR in Biomedicine, Vol. 25, No. 2, 01.02.2012, p. 332-339.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Localized 1H NMR spectroscopy in different regions of human brain in vivo at 7T
T2 - T 2 relaxation times and concentrations of cerebral metabolites
AU - Marjanska, Malgorzata
AU - Auerbach, Edward J
AU - Valabrègue, Romain
AU - Van de Moortele, Pierre-Francois
AU - Adriany, Gregor
AU - Garwood, Michael
PY - 2012/2/1
Y1 - 2012/2/1
N2 - At the high field strength of 7T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures other than the occipital lobe. The purpose of the present study was to obtain high-quality spectra from various brain regions at 7T and to quantify the concentrations of different metabolites. To obtain concentrations of metabolites within four different regions of the brain, such as the occipital lobe, motor cortex, basal ganglia and cerebellum, the T 2 relaxation times of the singlets and J-coupled metabolites in these regions were measured for the first time at 7T. Our results demonstrate that high-quality, quantifiable spectra can be obtained in regions other than the occipital lobe at 7T utilizing a 16-channel transceiver coil and B 1 + shimming.
AB - At the high field strength of 7T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures other than the occipital lobe. The purpose of the present study was to obtain high-quality spectra from various brain regions at 7T and to quantify the concentrations of different metabolites. To obtain concentrations of metabolites within four different regions of the brain, such as the occipital lobe, motor cortex, basal ganglia and cerebellum, the T 2 relaxation times of the singlets and J-coupled metabolites in these regions were measured for the first time at 7T. Our results demonstrate that high-quality, quantifiable spectra can be obtained in regions other than the occipital lobe at 7T utilizing a 16-channel transceiver coil and B 1 + shimming.
KW - Basal ganglia
KW - Cerebellum
KW - LCModel
KW - Motor cortex
KW - Occipital lobe
UR - http://www.scopus.com/inward/record.url?scp=84855984910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855984910&partnerID=8YFLogxK
U2 - 10.1002/nbm.1754
DO - 10.1002/nbm.1754
M3 - Article
C2 - 21796710
AN - SCOPUS:84855984910
VL - 25
SP - 332
EP - 339
JO - NMR in Biomedicine
JF - NMR in Biomedicine
SN - 0952-3480
IS - 2
ER -