Localized histiocytic sarcoma in a captive capybara (Hydrochoerus hydrochaeris)

Saralee Srivorakul, Kittikorn Boonsri, Thewarach Vechmanus, Pinich Boonthong, M. Gerard O'Sullivan, Kidsadagon Pringproa

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An irregular, subcutaneous mass (2x3x2 cm) located between the first and second digits of the left hindlimb of a nine-year-old, male, captive capybara (Hydrochoerus hydrochaeris) was biopsied. Microscopically, the mass scattered throughout the dermis. The neoplastic cells were arranged in solid-sheet patterns and comprised of pleomorphic histiocytic cells with pleomorphic nuclei and abundant eosinophillic cytoplasm. Mitotic figures were 2-3 cells/HPF. Numerous, multinucleated, giant cells, up to 10 nuclei/cells, were also prominently observed and found scattered throughout the mass. Immunohistochemically, the neoplastic cells were strongly positive for vimentin and ionized calcium-binding adaptor molecule 1 (Iba-1), while immunoreactivity for cytokeratin was negative. Based on histopathological and immunohistochemical characterizations, localized histiocytic sarcoma was diagnosed.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalThai Journal of Veterinary Medicine
Issue number1
StatePublished - Jan 1 2017


  • Capybara
  • Histiocytic sarcoma
  • Hydrochoerus hydrochaeris


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