Localization of tritiated digoxin in the rat eye

William Lissner; James E. Greenlee; J. Douglas Cameron; Seymour B. Goren

doi:10.1016/0002-9394(71)90860-9

Localization of tritiated digoxin in the rat eye

William Lissner, James E. Greenlee, J. Douglas Cameron, Seymour B. Goren

Ophthalmology & Visual Neurosciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Localization of tritium-labeled digoxin in the eye of the rat was investigated, using autoradiographic and scintillographic techniques. The iris and inner retinal layers were found to be the primary binding sites of digitalis. Negligible amounts of radioactivity were found in the outer retinal layers, brain, and optic nerve.

Original language	English (US)
Pages (from-to)	608-614
Number of pages	7
Journal	American journal of ophthalmology
Volume	72
Issue number	3
DOIs	https://doi.org/10.1016/0002-9394(71)90860-9
State	Published - Sep 1971

Bibliographical note

Funding Information:
From the Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois. This study was supported in part by Public Health Service Research Grant R01EY00389 from the National Eye Institute, a National Society for the Prevention of Blindness Research Grant and The Carrie Blanche Levy Fund for Experimental Studies in Ophthalmology of the Chicago Wesley Memorial Hospital.

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title = "Localization of tritiated digoxin in the rat eye",

abstract = "Localization of tritium-labeled digoxin in the eye of the rat was investigated, using autoradiographic and scintillographic techniques. The iris and inner retinal layers were found to be the primary binding sites of digitalis. Negligible amounts of radioactivity were found in the outer retinal layers, brain, and optic nerve.",

author = "William Lissner and Greenlee, {James E.} and Cameron, {J. Douglas} and Goren, {Seymour B.}",

note = "Funding Information: From the Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois. This study was supported in part by Public Health Service Research Grant R01EY00389 from the National Eye Institute, a National Society for the Prevention of Blindness Research Grant and The Carrie Blanche Levy Fund for Experimental Studies in Ophthalmology of the Chicago Wesley Memorial Hospital.",

year = "1971",

month = sep,

doi = "10.1016/0002-9394(71)90860-9",

language = "English (US)",

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pages = "608--614",

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AU - Lissner, William

AU - Greenlee, James E.

AU - Cameron, J. Douglas

AU - Goren, Seymour B.

N1 - Funding Information: From the Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois. This study was supported in part by Public Health Service Research Grant R01EY00389 from the National Eye Institute, a National Society for the Prevention of Blindness Research Grant and The Carrie Blanche Levy Fund for Experimental Studies in Ophthalmology of the Chicago Wesley Memorial Hospital.

PY - 1971/9

Y1 - 1971/9

N2 - Localization of tritium-labeled digoxin in the eye of the rat was investigated, using autoradiographic and scintillographic techniques. The iris and inner retinal layers were found to be the primary binding sites of digitalis. Negligible amounts of radioactivity were found in the outer retinal layers, brain, and optic nerve.

AB - Localization of tritium-labeled digoxin in the eye of the rat was investigated, using autoradiographic and scintillographic techniques. The iris and inner retinal layers were found to be the primary binding sites of digitalis. Negligible amounts of radioactivity were found in the outer retinal layers, brain, and optic nerve.

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ER -

Localization of tritiated digoxin in the rat eye

Abstract

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