Localization of Prostaglandin-Forming Cyclooxygenase in Middle Ear and External Canal Tissue

Timothy T.K. Jung, S. K. Juhn, Alfred F. Michael

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Prostaglandins were found in the middle ear effusion and may play an important role in inflammation and bone resorption occurring in otitis media. With the use of an immunohistochemical technique, prostaglandin cyclooxygenase was localized in epithelial cells of human skin, endothelial cells of arterioles, mononuclear leukocytes and fibroblasts of human middle ear mucosa and granulation tissue, epithelial cells of chinchilla middle ear mucosa, and the external auditory canal skin.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalOtolaryngology-Head and Neck Surgery
Volume91
Issue number2
DOIs
StatePublished - Apr 1983

Bibliographical note

Funding Information:
Supported by research grant NS 14538 from the Public Health Service and institutional fellowship 09014156 from the National Institutes of Health.

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