Localization of neuronal histamine in rat brain

Barbara J. Wilcox, Virginia S Seybold

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Antisera to histamine were generated by immunization of albino guinea pigs with a complex of histamine and methylated-bovine serum albumin. Characterization of the antisera and preliminary mapping of histaminergic neurons were conducted on brain tissue from normal and experimentally manipulated rats. Using immunofluorescence, histamine-like immunoreactive cell bodies were revealed in the lateral hypothalamus, and fibers were stained in the hypothalamus, cortex, amygdala and hippocampus.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalNeuroscience Letters
Issue number2
StatePublished - Apr 16 1982


  • antiserum
  • colchicine
  • histamine
  • hypothalamus
  • immunofluorescence

Fingerprint Dive into the research topics of 'Localization of neuronal histamine in rat brain'. Together they form a unique fingerprint.

Cite this