Localization and socialization: Experimental insights into the functional architecture of IP3 receptors

Luis Diambra, Jonathan S. Marchant

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Inositol 1,4,5-trisphosphate (IP3) -evoked Ca2+ signals display great spatiotemporal malleability. This malleability depends on diversity in both the cellular organization and in situ functionality of IP 3 receptors (IP3 Rs) that regulate Ca2+ release from the endoplasmic reticulum (ER). Recent experimental data imply that these considerations are not independent, such that-as with other ion channels-the local organization of IP3 Rs impacts their functionality, and reciprocally IP3 R activity impacts their organization within native ER membranes. Here, we (i) review experimental data that lead to our understanding of the "functional architecture" of IP3 Rs within the ER, (ii) propose an updated terminology to span the organizational hierarchy of IP3 Rs observed in intact cells, and (iii) speculate on the physiological significance of IP3 R socialization in Ca 2+ dynamics, and consequently the emerging need for modeling studies to move beyond gridded, planar, and static simulations of IP3 R clustering even over short experimental timescales.

Original languageEnglish (US)
Article number037103
Issue number3
StatePublished - 2009

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