Localisation of bioactive metabolites in marine sponges

D. John Faulkner, Mary Kay Harper, Christine E. Salomon, Eric W. Schmidt

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Marine natural product chemists have often proposed that bioactive sponge metabolites are produced by symbiotic micro-organisms. This paper discusses the rationale for these proposals, reviews the strengths and weaknesses of methods that are available to test such hypotheses and reports some experimental studies. The conclusion reached from the research to date is that it is too early to make generalisations concerning either the role of symbionts in the biosynthesis of sponge metabolites or even the best techniques for studying the cellular localisation of bioactive metabolites.

Original languageEnglish (US)
Pages (from-to)167-173
Number of pages7
JournalMemoirs of the Queensland Museum
Volume44
Issue number1-2
StatePublished - Jun 30 1999
Externally publishedYes

Keywords

  • Aplysina fistularis
  • Bioactive metabolites
  • Cyanobacteria
  • Dysidea herbacea
  • Filamentous eubacteria
  • Jaspis splendens
  • Oceanapia sagittaria
  • Porifera
  • Symbiosis
  • Theonella swinhoei

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