Local oral delivery agents with anti-biofilm properties for the treatment of periodontitis and peri-implantitis. A narrative review

Shorouk Elnagdy, Michail Raptopoulos, Ioannis Kormas, Alessandro Pedercini, Larry F. Wolff

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Despite many discoveries over the past 20 years regarding the etiopathogenesis of periodontal and peri-implant diseases, as well as significant advances in our understanding of microbial biofilms, the incidence of these pathologies continues to rise. For this reason, it was clear that other strategies were needed to eliminate biofilms. In this review, the literature database was searched for studies on locally delivered synthetic agents that exhibit anti-biofilm properties and their potential use in the treatment of two important oral diseases: periodontitis and peri-implantitis.

Original languageEnglish (US)
Article number5661
JournalMolecules
Volume26
Issue number18
DOIs
StatePublished - Sep 2021

Bibliographical note

Funding Information:
This study was supported by a Division of Periodontal Research Grant (Wolff, LF).We would like to thank J. Michael Stolley (StolleyScientificIllustration) for the designing and preparation of the included illustrations.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Anti-biofilm
  • Biofilm
  • Oral cavity
  • Peri-implantitis
  • Periodontitis

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