Local onset of voltage and calcium alternans in the heart

Stephen D. McIntyre, Yoichiro Mori, Elena G. Tolkacheva

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A beat-to-beat variation in cardiac action potential durations (APD) is a phenomenon known as electrical alternons. Alternons desynchronizes depolarization, increases dispersion of refractoriness and creates a sub strate for ventricular fibrillation. In the heart, APD alternons can be accompanied by alternons in intracellular calcium ([Ca2+]i) transients. Recently, we demonstrated experimentally that the onset of APD alternons in the heart is a local phenomenon that undergoes complex spatio temporal dynamics as pacing rate increases. Moreover, the local onset of APD alternons can be predicted by measuring the restitution properties of periodically paced cardiac tissue. The purpose of this research is to investigate the interplay between local onsets of APD and [Ca2+]i alternons using 2D simulation of action potential model of cardiac myocytes.

Original languageEnglish (US)
Title of host publicationASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, DSCC 2011
Pages607-610
Number of pages4
DOIs
StatePublished - Dec 1 2011
EventASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, DSCC 2011 - Arlington, VA, United States
Duration: Oct 31 2011Nov 2 2011

Publication series

NameASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, DSCC 2011
Volume2

Other

OtherASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, DSCC 2011
CountryUnited States
CityArlington, VA
Period10/31/1111/2/11

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McIntyre, S. D., Mori, Y., & Tolkacheva, E. G. (2011). Local onset of voltage and calcium alternans in the heart. In ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, DSCC 2011 (pp. 607-610). (ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, DSCC 2011; Vol. 2). https://doi.org/10.1115/DSCC2011-6148