Local delivery of zoledronate from a poly (D,L-lactide) - Coating increases fixation of press-fit implants

Thomas Jakobsen, Joan E. Bechtold, Kjeld Søballe, Thomas Jensen, Stefan Greiner, Marianne T. Vestermark, Jørgen Baas

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Early secure fixation of total joint replacements is crucial for long-term survival. Antiresorptive agents such as bisphosphonates have been shown to increase implant fixation. We investigated whether local delivery of zoledronate from poly-D, L-lactide (PDLLA)-coated implants could improve implant fixation and osseointegration. Experimental titanium implants were bilaterally inserted press-fit into the proximal tibiae of 10 dogs. On one side the implant was coated with PDLLA containing zoledronate. The contralateral implant was uncoated and used as control. Observation period was 12 weeks. Implant fixation was evaluated with histomorphometry and biomechanical push-out test. We found an approximately twofold increase in all biomechanical parameters when comparing data from the zoledronate group with their respective controls. Histomorphometry showed increased amount of preserved bone and increased bone formation around the zoledronate implants. This study indicates that local delivery of zoledronate from a PDDLA coating has the potential to increase implant fixation.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalJournal of Orthopaedic Research
Issue number1
StatePublished - Jan 1 2016

Bibliographical note

Funding Information:
Zoledronate was donated by Novartis (Novartis Pharma AG, Basel, Switzerland). Implants was donated by Depuy (Depuy Orthopaedics, Inc.).

Publisher Copyright:
© 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.


  • bisphosphonate
  • implant fixation


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