Living on the edge: network neuroscience beyond nodes

Network neuroscience has emphasized the connectional properties of neural elements – cells, populations, and regions. This has come at the expense of the anatomical and functional connections that link these elements to one another. A new perspective – namely one that emphasizes 'edges' – may prove fruitful in addressing outstanding questions in network neuroscience. We highlight one recently proposed 'edge-centric' method and review its current applications, merits, and limitations. We also seek to establish conceptual and mathematical links between this method and previously proposed approaches in the network science and neuroimaging literature. We conclude by presenting several avenues for future work to extend and refine existing edge-centric analysis.