Living donor kidney allograft survival ≥ 50 years

Oscar K. Serrano, Arthur J. Matas

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The first successful kidney transplant occurred in 1954. Since then, long-term graft survival has been an elusive idealistic goal of transplantation. Yet 62 years later, we know of only 6 kidney transplant recipients who have achieved ≥ 50-year graft survival while being on no immunosuppression or a substantially reduced regimen. Herein, we report graft survival ≥ 50 years in 2 living donor recipients who have been maintained on standard-of-care immunosuppression the entire time. For our 2 recipients, their living donor's altruism altered the course, length, and quality of their life, which by all accounts can be deemed normal: They attended college, held jobs, had successful pregnancies, raised families, and were productive members of society. Both donors are still alive and well, more than 50 years post-donation; both have an acceptable GFR and normal blood pressure, with hyperlipidemia as their only medical problem. These 2 intertwined stories illustrate the tremendous potential of a successful kidney transplant: long-term survival with a normal lifestyle and excellent quality of life, even after more than 5 decades on full-dose immunosuppression.

Original languageEnglish (US)
Article numbere12938
JournalClinical Transplantation
Volume31
Issue number5
DOIs
StatePublished - May 2017

Keywords

  • donor
  • kidney
  • living
  • long
  • survival
  • term
  • transplant

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