Liver Regeneration in the Acute Liver Failure Patient

Keith M. Wirth, Scott Kizy, Clifford J Steer

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Liver regeneration after simple resection represents a unique process in which the organ returns to its original size and histologic structure. Over the past 30 years, there has been significant progress in elucidating the mechanisms associated with regeneration after loss of hepatic mass. Liver regeneration after acute liver failure shares several of these classical pathways. It differs, however, in key processes, including the role of both differentiated and stemlike cells. This article outlines these differences in addition to new molecular mechanisms, including immunomodulation, microRNAs, and the gut-liver axis. In addition, applications to the patient population, including prognostication and stem cell therapies, are explored.

Original languageEnglish (US)
Pages (from-to)269-287
Number of pages19
JournalClinics in liver disease
Issue number2
StatePublished - May 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.


  • Acute liver failure
  • Cytokines
  • Growth factors
  • Homeostasis
  • MicroRNAs
  • Partial hepatectomy
  • Regeneration
  • Stem cells


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