Liver Regeneration in Acute and Acute-on-Chronic Liver Failure

Research output: Chapter in Book/Report/Conference proceedingChapter


Liver regeneration is a unique process in which the organ returns to its original size, histologic structure and normal metabolic function. The past several decades have identified many of the mechanisms associated with regeneration after hepatic injury. Liver regeneration in acute liver failure, as well as acute on chronic liver injury, has provided crucial information regarding pathways of regeneration beyond what the classical models of partial hepatectomy have shown. There is a growing body of data regarding cellular differentiation and stem cell involvement in the regenerative process of the liver that has been uncovered in these clinically relevant models. In this chapter, we describe the common and unique details of these myriad molecular mechanisms, including immunomodulation, microRNAs, and the gut-liver axis. Key to these pathways are the role of cellular signaling and stem cells as they relate to liver regeneration in both acute and acute on chronic injury.

Original languageEnglish (US)
Title of host publicationLiver Failure
Subtitle of host publicationAcute and Acute on Chronic
PublisherSpringer International Publishing
Number of pages26
ISBN (Electronic)9783030509835
ISBN (Print)9783030509828
StatePublished - Oct 30 2020

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2020.


  • Acute liver failure
  • Acute on chronic liver failure
  • Cytokines
  • Growth factors
  • Homeostasis
  • MicroRNAs
  • Partial hepatectomy
  • Regeneration
  • Stem cells


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