Liver Physiology and Disease Acute Cholestasis in Patients with Toxic-Shock Syndrome

Glenn R. Gourley, P. Joan Chesney, Jeffrey P. Davis, Gerard B. Odell

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Serum liver function tests were performed in 22 females fulfilling the criteria for toxic-shock syndrome. All patients showed evidence of hepatic dysfunction during their hospital course. These findings included hyperbilirubinemia in the absence of laboratory evidence for significant hemolysis, mild elevation of the transaminases, threefold increase in their serum bile salt concentration, and hypoalbuminemia. These findings are best explained by hypoperfusion of the liver and a canalicular injury secondary to staphylococcal exotoxin. Cholestasis appears to be a universal finding in toxic-shock syndrome.

Original languageEnglish (US)
Pages (from-to)928-931
Number of pages4
JournalGastroenterology
Volume81
Issue number5
DOIs
StatePublished - Jan 1 1981

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