Liver aquaporins: significance in canalicular and ductal bile formation.

Raúl A. Marinelli; Sergio A. Gradilone; Flavia I. Carreras; Giuseppe Calamita; Guillermo L. Lehmann

doi:10.1016/s1665-2681(19)32090-3

Liver aquaporins: significance in canalicular and ductal bile formation.

Raúl A. Marinelli, Sergio A. Gradilone, Flavia I. Carreras, Giuseppe Calamita, Guillermo L. Lehmann

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Abstract Bile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the vectorial movement of solutes and osmotically driven water molecules. Hepatocytes and cholangiocytes express aquaporins, specialized membrane channel proteins that facilitate the osmotic transport of water. In this review, we provide a summary of what is known on liver AQPs and their significance in canalicular and ductal bile formation under normal and pathological conditions.

Original language	English (US)
Pages (from-to)	130-136
Number of pages	7
Journal	Annals of hepatology : official journal of the Mexican Association of Hepatology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/s1665-2681(19)32090-3
State	Published - 2004
Externally published	Yes

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Liver aquaporins : significance in canalicular and ductal bile formation. / Marinelli, Raúl A.; Gradilone, Sergio A.; Carreras, Flavia I.; Calamita, Giuseppe; Lehmann, Guillermo L.

In: Annals of hepatology : official journal of the Mexican Association of Hepatology, Vol. 3, No. 4, 2004, p. 130-136.

Research output: Contribution to journal › Review article › peer-review

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abstract = "Abstract Bile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the vectorial movement of solutes and osmotically driven water molecules. Hepatocytes and cholangiocytes express aquaporins, specialized membrane channel proteins that facilitate the osmotic transport of water. In this review, we provide a summary of what is known on liver AQPs and their significance in canalicular and ductal bile formation under normal and pathological conditions.",

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AU - Marinelli, Raúl A.

AU - Gradilone, Sergio A.

AU - Carreras, Flavia I.

AU - Calamita, Giuseppe

AU - Lehmann, Guillermo L.

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N2 - Abstract Bile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the vectorial movement of solutes and osmotically driven water molecules. Hepatocytes and cholangiocytes express aquaporins, specialized membrane channel proteins that facilitate the osmotic transport of water. In this review, we provide a summary of what is known on liver AQPs and their significance in canalicular and ductal bile formation under normal and pathological conditions.

AB - Abstract Bile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the vectorial movement of solutes and osmotically driven water molecules. Hepatocytes and cholangiocytes express aquaporins, specialized membrane channel proteins that facilitate the osmotic transport of water. In this review, we provide a summary of what is known on liver AQPs and their significance in canalicular and ductal bile formation under normal and pathological conditions.

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