LIS1: From cortical malformation to essential protein of cellular dynamics

Richard J. Leventer, Carlos Cardoso, David H. Ledbetter, William B. Dobyns

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


The LIS1 gene was cloned following the study of children with lissencephaly and cytogenetic abnormalities involving chromosome 17p, however, the role of the LIS1 protein in normal cortical development is not precisely defined. LIS1 is a component of evolutionarily conserved intracellular multiprotein complexes and recent literature shows that these complexes are essential, not only for neuronal migration, but they might also be fundamental components of the machinery for cell proliferation and intracellular transport.

Original languageEnglish (US)
Pages (from-to)489-492
Number of pages4
JournalTrends in Neurosciences
Issue number9
StatePublished - Sep 1 2001
Externally publishedYes


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