Liquid-chromatographic determination of fleroxacin in serum and urine

W. M. Awni; J. A. Maloney; Karen L Heim-Duthoy

doi:10.1093/clinchem/34.11.2330

Liquid-chromatographic determination of fleroxacin in serum and urine

W. M. Awni, J. A. Maloney, Karen L Heim-Duthoy

Pharmaceutical Care and Health Systems

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Abstract

This highly sensitive, accurate, and reproducible HPLC method for determining fleroxacin in human serum and urine makes use of a common C18 column, a fluorescence detector, and an internal standard. Serum samples require a simple extraction procedure; urine must be diluted. The method, which we have used extensively for pharmacokinetic assessment of fleroxacin in patients, measures concentrations as low as 5 μg/L.

Original language	English (US)
Pages (from-to)	2330-2332
Number of pages	3
Journal	Clinical chemistry
Volume	34
Issue number	11
DOIs	https://doi.org/10.1093/clinchem/34.11.2330
State	Published - 1988

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10.1093/clinchem/34.11.2330

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title = "Liquid-chromatographic determination of fleroxacin in serum and urine",

abstract = "This highly sensitive, accurate, and reproducible HPLC method for determining fleroxacin in human serum and urine makes use of a common C18 column, a fluorescence detector, and an internal standard. Serum samples require a simple extraction procedure; urine must be diluted. The method, which we have used extensively for pharmacokinetic assessment of fleroxacin in patients, measures concentrations as low as 5 μg/L.",

author = "Awni, {W. M.} and Maloney, {J. A.} and Heim-Duthoy, {Karen L}",

year = "1988",

doi = "10.1093/clinchem/34.11.2330",

language = "English (US)",

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T1 - Liquid-chromatographic determination of fleroxacin in serum and urine

AU - Awni, W. M.

AU - Maloney, J. A.

AU - Heim-Duthoy, Karen L

PY - 1988

Y1 - 1988

N2 - This highly sensitive, accurate, and reproducible HPLC method for determining fleroxacin in human serum and urine makes use of a common C18 column, a fluorescence detector, and an internal standard. Serum samples require a simple extraction procedure; urine must be diluted. The method, which we have used extensively for pharmacokinetic assessment of fleroxacin in patients, measures concentrations as low as 5 μg/L.

AB - This highly sensitive, accurate, and reproducible HPLC method for determining fleroxacin in human serum and urine makes use of a common C18 column, a fluorescence detector, and an internal standard. Serum samples require a simple extraction procedure; urine must be diluted. The method, which we have used extensively for pharmacokinetic assessment of fleroxacin in patients, measures concentrations as low as 5 μg/L.

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DO - 10.1093/clinchem/34.11.2330

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JO - Clinical chemistry

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ER -

Liquid-chromatographic determination of fleroxacin in serum and urine

Abstract

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