Liquid-chromatographic determination of fleroxacin in serum and urine

W. M. Awni, J. A. Maloney, Karen L Heim-Duthoy

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


This highly sensitive, accurate, and reproducible HPLC method for determining fleroxacin in human serum and urine makes use of a common C18 column, a fluorescence detector, and an internal standard. Serum samples require a simple extraction procedure; urine must be diluted. The method, which we have used extensively for pharmacokinetic assessment of fleroxacin in patients, measures concentrations as low as 5 μg/L.

Original languageEnglish (US)
Pages (from-to)2330-2332
Number of pages3
JournalClinical chemistry
Issue number11
StatePublished - 1988


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