Liposomal targeting through peptide-amphiphile functionalization

Raymond Tu, Kishore Mohanty, Matthew Tirrell

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Peptide-conjugated lipid-like molecules may enhance the efficacy of liposomal drug-carrying assemblies offering the ability to target specific cell-types. Targeted liposomes are formed by partitioning a collagen-mimetic peptide-amphiphile into the bilayer membrane. These self-assemblies are capable of promoting the binding of vesicles to cells with only a small molar fraction of the peptide-amphiphile. Moreover, liposomes including lipids with polyethylene glycol (PEG) head groups of various molecular weights can controllably 'mask' the targeting functionality tuning the residence time.

Original languageEnglish (US)
Pages (from-to)36-41
Number of pages6
JournalAmerican Pharmaceutical Review
Volume7
Issue number2
StatePublished - Mar 2004
Externally publishedYes

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