Lipoprotein-associated phospholipase A2 and venous thromboembolism: A prospective study

Aaron R. Folsom, Pamela L. Lutsey, Nicholas S. Roetker, Christie M. Ballantyne, Ron C. Hoogeveen, Wayne D. Rosamond, Mary Cushman

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory marker associated positively with atherothrombotic risk. Whether Lp-PLA2 is related to risk of venous thromboembolism (VTE) is incompletely studied. Methods We assessed Lp-PLA 2 activity in 10,687 Atherosclerosis Risk in Communities (ARIC) Study participants and followed them a median of 8.3 years (from 1996-98 through 2005) for VTE occurrence (n = 226). Results There was no significant association between baseline Lp-PLA2 quartiles and risk of VTE, neither overall nor stratified as provoked or unprovoked. Adjusted for other risk factors, the hazard ratios (95% confidence interval) of total VTE across quartiles of Lp-PLA2 were 1.0 (reference), 0.95 (0.64, 1.42), 1.03 (0.69, 1.56), and 1.26 (0.83, 1.91). In the subset of participants with LDL-cholesterol ≥ 130 mg/dL, hazard ratios of total VTE were 1.00, 1.39 (0.44, 4.44), 2.45 (0.84, 7.11), and 2.84 (0.99, 8.14). Conclusion Our study does not support the overall hypothesis that elevated Lp-PLA2 contributes to VTE occurrence in the general population. However, in the presence of high LDL-cholesterol there was some evidence that Lp-PLA2 may increase VTE risk.

Original languageEnglish (US)
Pages (from-to)44-46
Number of pages3
JournalThrombosis Research
Volume132
Issue number1
DOIs
StatePublished - Jul 2013

Bibliographical note

Funding Information:
This study was funded by the National Heart, Lung, and Blood Institute grant R01 HL59367 (LITE), and contracts ( HHSN268201100005C , HHSN268201100006C , HHSN268201100007C , HHSN268201100008C , HHSN268201100009C , HHSN268201100010C , HHSN268201100011C , and HHSN268201100012C ) (ARIC).

Keywords

  • Lipoprotein-associated phospholipase A
  • Prospective study
  • Pulmonary embolism
  • Venous thromboembolism

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