Lipopolysaccharide-lnduced toxic shock syndrome in rabbits

Christopher S. Stach; Patrick M. Schlievert

doi:10.1007/978-1-4939-3344-0_5

Lipopolysaccharide-lnduced toxic shock syndrome in rabbits

Christopher S. Stach
, Patrick M. Schlievert

Biotechnology Institute

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Enhancement of susceptibility to lipopolysaccharide (LPS; endotoxin) is a defining characteristic of Staphylococcus aureus superantigens. At the time of this publication, there are 24 identified staphylococcal superantigens (SAgs), some of which have yet to be fully characterized. Testing the capacity of superantigens to potentiate LPS sensitivity is essential to characterize the role of these proteins in disease development. Here we describe how to perform studies of the enhancement of LPS-induced toxic shock syndrome in rabbits. This protocol also provides information on a second important activity of superantigens: the production of fever.

Original language	English (US)
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	67-71
Number of pages	5
DOIs	https://doi.org/10.1007/978-1-4939-3344-0_5
State	Published - 2016

Publication series

Name	Methods in Molecular Biology
Volume	1396
ISSN (Print)	1064-3745

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media New York 2016.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Endotoxin enhancement
LPS-induced toxic shock syndrome
Staphylococcus aureus
Superantigens

Publisher link

10.1007/978-1-4939-3344-0_5

Find It

Find It at U of M Libraries

Cite this

@inbook{84271df0db774d8b8624f3f7d2ed5c62,

title = "Lipopolysaccharide-lnduced toxic shock syndrome in rabbits",

abstract = "Enhancement of susceptibility to lipopolysaccharide (LPS; endotoxin) is a defining characteristic of Staphylococcus aureus superantigens. At the time of this publication, there are 24 identified staphylococcal superantigens (SAgs), some of which have yet to be fully characterized. Testing the capacity of superantigens to potentiate LPS sensitivity is essential to characterize the role of these proteins in disease development. Here we describe how to perform studies of the enhancement of LPS-induced toxic shock syndrome in rabbits. This protocol also provides information on a second important activity of superantigens: the production of fever.",

keywords = "Endotoxin enhancement, LPS-induced toxic shock syndrome, Staphylococcus aureus, Superantigens",

author = "Stach, \{Christopher S.\} and Schlievert, \{Patrick M.\}",

note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2016.",

year = "2016",

doi = "10.1007/978-1-4939-3344-0\_5",

language = "English (US)",

series = "Methods in Molecular Biology",

publisher = "Humana Press Inc.",

pages = "67--71",

booktitle = "Methods in Molecular Biology",

}

TY - CHAP

T1 - Lipopolysaccharide-lnduced toxic shock syndrome in rabbits

AU - Stach, Christopher S.

AU - Schlievert, Patrick M.

N1 - Publisher Copyright: © Springer Science+Business Media New York 2016.

PY - 2016

Y1 - 2016

N2 - Enhancement of susceptibility to lipopolysaccharide (LPS; endotoxin) is a defining characteristic of Staphylococcus aureus superantigens. At the time of this publication, there are 24 identified staphylococcal superantigens (SAgs), some of which have yet to be fully characterized. Testing the capacity of superantigens to potentiate LPS sensitivity is essential to characterize the role of these proteins in disease development. Here we describe how to perform studies of the enhancement of LPS-induced toxic shock syndrome in rabbits. This protocol also provides information on a second important activity of superantigens: the production of fever.

AB - Enhancement of susceptibility to lipopolysaccharide (LPS; endotoxin) is a defining characteristic of Staphylococcus aureus superantigens. At the time of this publication, there are 24 identified staphylococcal superantigens (SAgs), some of which have yet to be fully characterized. Testing the capacity of superantigens to potentiate LPS sensitivity is essential to characterize the role of these proteins in disease development. Here we describe how to perform studies of the enhancement of LPS-induced toxic shock syndrome in rabbits. This protocol also provides information on a second important activity of superantigens: the production of fever.

KW - Endotoxin enhancement

KW - LPS-induced toxic shock syndrome

KW - Staphylococcus aureus

KW - Superantigens

UR - https://www.scopus.com/pages/publications/84950292450

UR - https://www.scopus.com/pages/publications/84950292450#tab=citedBy

U2 - 10.1007/978-1-4939-3344-0_5

DO - 10.1007/978-1-4939-3344-0_5

M3 - Chapter

C2 - 26676037

AN - SCOPUS:84950292450

T3 - Methods in Molecular Biology

SP - 67

EP - 71

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -

Lipopolysaccharide-lnduced toxic shock syndrome in rabbits

Abstract

Publication series

Bibliographical note

UN SDGs

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this