Lipopolysaccharide-lnduced toxic shock syndrome in rabbits

Christopher Stach, Patrick M. Schlievert

Research output: Chapter in Book/Report/Conference proceedingChapter


Enhancement of susceptibility to lipopolysaccharide (LPS; endotoxin) is a defining characteristic of Staphylococcus aureus superantigens. At the time of this publication, there are 24 identified staphylococcal superantigens (SAgs), some of which have yet to be fully characterized. Testing the capacity of superanti­gens to potentiate LPS sensitivity is essential to characterize the role of these proteins in disease develop­ment. Here we describe how to perform studies of the enhancement of LPS-induced toxic shock syndrome in rabbits. This protocol also provides information on a second important activity of superantigens: the production of fever.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages5
StatePublished - Jan 1 2016

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Endotoxin enhancement
  • LPS-induced toxic shock syndrome
  • Staphylococcus aureus
  • Superantigens


Dive into the research topics of 'Lipopolysaccharide-lnduced toxic shock syndrome in rabbits'. Together they form a unique fingerprint.

Cite this