Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism

Yuanyuan Zhang, Hong Guo, Jessica A. Deis, Mara G. Mashek, Ming Zhao, Donsanjiv Ariyakumar, Anibal G. Armien, David A. Bernlohr, Douglas G. Mashek, Xiaoli Chen

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Background: Lipocalin 2 is a recently characterized adipokine/cytokine known to be a critical regulator of metabolic homeostasis. Results: Lcn2 deficiency impairs BAT activation by reducing peroxisomal and mitochondrial oxidation of lipids and the recruitment of functional brown adipocytes. Conclusion: We demonstrate a novel role of Lcn2 in oxidative metabolism and BAT activation via a nonadrenergic pathway. Significance: Our findings advance understanding of the adrenergic independent mechanism for BAT activation.

Original languageEnglish (US)
Pages (from-to)22063-22077
Number of pages15
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

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