Lipids, oxidation, and cardiovascular disease

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Blood cholesterol and LDL levels are well-established risk factors for cardiovascular disease and, in particular, coronary heart disease. In recent years, the role of LDL in the pathogenesis of atherosclerosis, the underlying cause of coronary heart disease, has been studied extensively. These studies have highlighted the complexity of atherosclerotic processes and identified oxidative damage and inflammation as important components of the process. In addition, the formation and possible involvement of various oxidized lipids in atherosclerosis have been identified by the studies. The oxidized lipids include the products of oxidative enzymes, located in the vasculature, as well as nonspecific oxidation products. Many of these lipids have been found in atherosclerotic plaque and have potent bioactivities. Moreover, these oxidation products and, reactive oxygen and nitrogen species, have been linked with cellular signaling pathways that can influence the development of atherosclerosis.

Original languageEnglish (US)
Title of host publicationAtherosclerosis and Oxidant Stress
Subtitle of host publicationA New Perspective
PublisherSpringer US
Pages79-95
Number of pages17
ISBN (Print)9780387723457
DOIs
StatePublished - Dec 1 2008

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    Gross, M. D. (2008). Lipids, oxidation, and cardiovascular disease. In Atherosclerosis and Oxidant Stress: A New Perspective (pp. 79-95). Springer US. https://doi.org/10.1007/978-0-387-72347-1_5