Lipid Requirement for μ Opioid Receptor Binding

Jun‐Ichi ‐I Hasegawa, Horace H. Loh, Nancy M. Lee

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Abstract: We have previously shown that a partially purified μ opioid receptor from bovine brain requires lipids to exhibit full binding activity. In the present report, we have determined the specificity of this lipid requirement. Lipids active in this regard were found always to contain an acidic head group and a fatty acid with two or more double bonds. Free, polyunsaturated fatty acids were also able to confer high binding activity on the partially purified opioid receptor. The possible roles lipids play in opioid binding are discussed in light of these data.

Original languageEnglish (US)
Pages (from-to)1007-1012
Number of pages6
JournalJournal of Neurochemistry
Volume49
Issue number4
DOIs
StatePublished - Oct 1987

Keywords

  • Acidic lipid
  • Double bond
  • Fatty acid
  • μ opioid receptor

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