TY - CHAP
T1 - Lipid metabolism in adipose tissue
AU - Hertzel, Ann V.
AU - Thompson, Brian R.
AU - Wiczer, Brian M.
AU - Bernlohr, David A.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - This chapter focuses on the biochemistry of lipid metabolism in the adipocyte. Adipocytes make up approximately one-half of the cells in adipose tissue, the remainder being blood and endothelial cells, adipose precursor cells of varying degrees of differentiation, macrophages, and fibroblasts. In humans, small clusters of adipocytes are present that increase in size during gestation. Larger clusters of fat cells are associated with tissue vascularization and a general increase in cluster size is positively correlated with larger blood vessels. Paracrine/autocrine factors play a significant role in both capillary growth and adipose conversion. Recent advances have demonstrated that the adipocyte is not a passive lipid storage depot but a dynamic cell that plays a fundamental role in energy balance and overall body homeostasis. Moreover, the fat cell functions as a sensor of lipid levels, transmitting information to a neural circuit affecting major biological processes including hunger, sleep, and reproduction.
AB - This chapter focuses on the biochemistry of lipid metabolism in the adipocyte. Adipocytes make up approximately one-half of the cells in adipose tissue, the remainder being blood and endothelial cells, adipose precursor cells of varying degrees of differentiation, macrophages, and fibroblasts. In humans, small clusters of adipocytes are present that increase in size during gestation. Larger clusters of fat cells are associated with tissue vascularization and a general increase in cluster size is positively correlated with larger blood vessels. Paracrine/autocrine factors play a significant role in both capillary growth and adipose conversion. Recent advances have demonstrated that the adipocyte is not a passive lipid storage depot but a dynamic cell that plays a fundamental role in energy balance and overall body homeostasis. Moreover, the fat cell functions as a sensor of lipid levels, transmitting information to a neural circuit affecting major biological processes including hunger, sleep, and reproduction.
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U2 - 10.1016/B978-044453219-0.50012-X
DO - 10.1016/B978-044453219-0.50012-X
M3 - Chapter
AN - SCOPUS:78149309187
SN - 9780444532190
SP - 277
EP - 304
BT - Biochemistry of Lipids, Lipoproteins and Membranes
PB - Elsevier
ER -