Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1

Charles P. Najt, Salmaan A. Khan, Timothy D. Heden, Bruce A. Witthuhn, Minervo Perez, Jason L. Heier, Linnea E. Mead, Mallory P. Franklin, Kenneth K. Karanja, Mark J. Graham, Mara T. Mashek, David A. Bernlohr, Laurie Parker, Lisa S. Chow, Douglas G. Mashek

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Najt et al. identify the first-known endogenous allosteric modulator of SIRT1 and characterize a lipid droplet-nuclear signaling axis that underlies the known metabolic benefits of monounsaturated fatty acids and PLIN5.

Original languageEnglish (US)
Pages (from-to)810-824.e8
JournalMolecular Cell
Volume77
Issue number4
DOIs
StatePublished - Feb 20 2020

Keywords

  • ATGL
  • fatty acids
  • lipid droplets
  • lipolysis
  • MUFA
  • olive oil
  • oxidative metabolism
  • PGC-1α
  • PLIN5
  • SIRT1

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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