Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1

Charles P. Najt; Salmaan A. Khan; Timothy D. Heden; Bruce A. Witthuhn; Minervo Perez; Jason L. Heier; Linnea E. Mead; Mallory P. Franklin; Kenneth K. Karanja; Mark J. Graham; Mara T. Mashek; David A. Bernlohr; Laurie Parker; Lisa S. Chow; Douglas G. Mashek

doi:10.1016/j.molcel.2019.12.003

Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1

Charles P. Najt, Salmaan A. Khan, Timothy D. Heden, Bruce A. Witthuhn, Minervo Perez, Jason L. Heier, Linnea E. Mead, Mallory P. Franklin, Kenneth K. Karanja, Mark J. Graham, Mara T. Mashek, David A. Bernlohr, Laurie Parker, Lisa S. Chow, Douglas G. Mashek

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Najt et al. identify the first-known endogenous allosteric modulator of SIRT1 and characterize a lipid droplet-nuclear signaling axis that underlies the known metabolic benefits of monounsaturated fatty acids and PLIN5.

Original language	English (US)
Pages (from-to)	810-824.e8
Journal	Molecular Cell
Volume	77
Issue number	4
DOIs	https://doi.org/10.1016/j.molcel.2019.12.003
State	Published - Feb 20 2020

Keywords

ATGL
fatty acids
lipid droplets
lipolysis
MUFA
olive oil
oxidative metabolism
PGC-1α
PLIN5
SIRT1

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Access

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Cite this

Najt, C. P., Khan, S. A., Heden, T. D., Witthuhn, B. A., Perez, M., Heier, J. L., Mead, L. E., Franklin, M. P., Karanja, K. K., Graham, M. J., Mashek, M. T., Bernlohr, D. A., Parker, L., Chow, L. S., & Mashek, D. G. (2020). Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1. Molecular Cell, 77(4), 810-824.e8. https://doi.org/10.1016/j.molcel.2019.12.003

Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1. / Najt, Charles P.; Khan, Salmaan A.; Heden, Timothy D.; Witthuhn, Bruce A.; Perez, Minervo; Heier, Jason L.; Mead, Linnea E.; Franklin, Mallory P.; Karanja, Kenneth K.; Graham, Mark J.; Mashek, Mara T.; Bernlohr, David A.; Parker, Laurie ; Chow, Lisa S.; Mashek, Douglas G.

In: Molecular Cell, Vol. 77, No. 4, 20.02.2020, p. 810-824.e8.

Research output: Contribution to journal › Article

Najt, CP, Khan, SA, Heden, TD , Witthuhn, BA, Perez, M, Heier, JL, Mead, LE, Franklin, MP, Karanja, KK, Graham, MJ, Mashek, MT , Bernlohr, DA , Parker, L , Chow, LS & Mashek, DG 2020, 'Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1', Molecular Cell, vol. 77, no. 4, pp. 810-824.e8. https://doi.org/10.1016/j.molcel.2019.12.003

Najt, Charles P. ; Khan, Salmaan A. ; Heden, Timothy D. ; Witthuhn, Bruce A. ; Perez, Minervo ; Heier, Jason L. ; Mead, Linnea E. ; Franklin, Mallory P. ; Karanja, Kenneth K. ; Graham, Mark J. ; Mashek, Mara T. ; Bernlohr, David A. ; Parker, Laurie ; Chow, Lisa S. ; Mashek, Douglas G. / Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1. In: Molecular Cell. 2020 ; Vol. 77, No. 4. pp. 810-824.e8.

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abstract = "Najt et al. identify the first-known endogenous allosteric modulator of SIRT1 and characterize a lipid droplet-nuclear signaling axis that underlies the known metabolic benefits of monounsaturated fatty acids and PLIN5.",

keywords = "ATGL, fatty acids, lipid droplets, lipolysis, MUFA, olive oil, oxidative metabolism, PGC-1α, PLIN5, SIRT1",

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AU - Graham, Mark J.

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AU - Bernlohr, David A.

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