Lipid carrier proteins and ethanol

W. Gibson Wood, Nicolai A. Avdulov, Svetlana V. Chochina, Urule Igbavboa

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Ethanol has a pronounced effect on lipid homeostasis. It is our overall hypothesis that certain lipid carrier proteins are targets of acute and chronic ethanol exposure and that perturbation of these proteins induces lipid dysfunction leading to cellular pathophysiology. These proteins include both intracellular proteins and lipoproteins. This paper examines recent data on the interaction of ethanol with these proteins. In addition, new data are presented on the stimulatory effects of ethanol on low-density-lipoprotein (LDL)-mediated cholesterol uptake into fibroblasts and direct perturbation of the LDL apolipoprotein, apolipoprotein B. A cell model is presented that outlines potential mechanisms thought to be involved in ethanol perturbation of cholesterol transport and distribution.

Original languageEnglish (US)
Pages (from-to)114-118
Number of pages5
JournalJournal of biomedical science
Volume8
Issue number1
DOIs
StatePublished - Feb 6 2001

Keywords

  • Alcoholism
  • Apolipoproteins
  • Cardiovascular disease
  • Cholesterol
  • Ethanol
  • High-density lipoproteins
  • Lipids
  • Low-density lipoproteins
  • Reverse cholesterol transport

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