Lipid carrier proteins and ethanol

W. Gibson Wood; Nicolai A. Avdulov; Svetlana V. Chochina; Urule Igbavboa

doi:10.1159/000054021

Lipid carrier proteins and ethanol

W. Gibson Wood, Nicolai A. Avdulov, Svetlana V. Chochina, Urule Igbavboa

Pharmacology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Ethanol has a pronounced effect on lipid homeostasis. It is our overall hypothesis that certain lipid carrier proteins are targets of acute and chronic ethanol exposure and that perturbation of these proteins induces lipid dysfunction leading to cellular pathophysiology. These proteins include both intracellular proteins and lipoproteins. This paper examines recent data on the interaction of ethanol with these proteins. In addition, new data are presented on the stimulatory effects of ethanol on low-density-lipoprotein (LDL)-mediated cholesterol uptake into fibroblasts and direct perturbation of the LDL apolipoprotein, apolipoprotein B. A cell model is presented that outlines potential mechanisms thought to be involved in ethanol perturbation of cholesterol transport and distribution.

Original language	English (US)
Pages (from-to)	114-118
Number of pages	5
Journal	Journal of biomedical science
Volume	8
Issue number	1
DOIs	https://doi.org/10.1159/000054021
State	Published - Feb 6 2001

Keywords

Alcoholism
Apolipoproteins
Cardiovascular disease
Cholesterol
Ethanol
High-density lipoproteins
Lipids
Low-density lipoproteins
Reverse cholesterol transport

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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abstract = "Ethanol has a pronounced effect on lipid homeostasis. It is our overall hypothesis that certain lipid carrier proteins are targets of acute and chronic ethanol exposure and that perturbation of these proteins induces lipid dysfunction leading to cellular pathophysiology. These proteins include both intracellular proteins and lipoproteins. This paper examines recent data on the interaction of ethanol with these proteins. In addition, new data are presented on the stimulatory effects of ethanol on low-density-lipoprotein (LDL)-mediated cholesterol uptake into fibroblasts and direct perturbation of the LDL apolipoprotein, apolipoprotein B. A cell model is presented that outlines potential mechanisms thought to be involved in ethanol perturbation of cholesterol transport and distribution.",

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AU - Wood, W. Gibson

AU - Avdulov, Nicolai A.

AU - Chochina, Svetlana V.

AU - Igbavboa, Urule

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Y1 - 2001/2/6

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AB - Ethanol has a pronounced effect on lipid homeostasis. It is our overall hypothesis that certain lipid carrier proteins are targets of acute and chronic ethanol exposure and that perturbation of these proteins induces lipid dysfunction leading to cellular pathophysiology. These proteins include both intracellular proteins and lipoproteins. This paper examines recent data on the interaction of ethanol with these proteins. In addition, new data are presented on the stimulatory effects of ethanol on low-density-lipoprotein (LDL)-mediated cholesterol uptake into fibroblasts and direct perturbation of the LDL apolipoprotein, apolipoprotein B. A cell model is presented that outlines potential mechanisms thought to be involved in ethanol perturbation of cholesterol transport and distribution.

KW - Alcoholism

KW - Apolipoproteins

KW - Cardiovascular disease

KW - Cholesterol

KW - Ethanol

KW - High-density lipoproteins

KW - Lipids

KW - Low-density lipoproteins

KW - Reverse cholesterol transport

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Lipid carrier proteins and ethanol

Abstract

Keywords

UN SDGs

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