Linking Structure and Function in Macroscale Brain Networks

Laura E. Suárez, Ross D. Markello, Richard F. Betzel, Bratislav Misic

Research output: Contribution to journalReview articlepeer-review

388 Scopus citations

Abstract

Structure–function relationships are a fundamental principle of many naturally occurring systems. However, network neuroscience research suggests that there is an imperfect link between structural connectivity and functional connectivity in the brain. Here, we synthesize the current state of knowledge linking structure and function in macroscale brain networks and discuss the different types of models used to assess this relationship. We argue that current models do not include the requisite biological detail to completely predict function. Structural network reconstructions enriched with local molecular and cellular metadata, in concert with more nuanced representations of functions and properties, hold great potential for a truly multiscale understanding of the structure–function relationship.

Original languageEnglish (US)
Pages (from-to)302-315
Number of pages14
JournalTrends in Cognitive Sciences
Volume24
Issue number4
DOIs
StatePublished - Apr 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 The Authors

Keywords

  • connectivity
  • connectome
  • hierarchy
  • network
  • structure–function

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