Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer

Katherine L. Cook, Jessica L. Schwartz-Roberts, William T. Baumann, Robert Clarke

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ER+ breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.

Original languageEnglish (US)
Article numbere1023928
JournalMolecular and Cellular Oncology
Volume3
Issue number1
DOIs
StatePublished - Jan 2 2016

Keywords

  • ATG7
  • IRF1 tumor suppressor
  • autophagy
  • breast cancer
  • estrogen receptor
  • unfolded protein response

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