Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ER+ breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.
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© 2016, © 2016 Taylor & Francis Group, LLC.
- IRF1 tumor suppressor
- breast cancer
- estrogen receptor
- unfolded protein response