Linkage of the multiple endocrine neoplasia type 2B gene (MEN2B) to chromosome 10 markers linked to MEN2A

Robert A. Norum; Ronald G. Lafreniere; Lawrence W. O'Neal; Thomas F. Nikolai; J. P. Delaney; James C. Sisson; Hagay Sobol; Gilbert M. Lenoir; Bruce A.J. Ponder; Huntington F. Willard; Charles E. Jackson

doi:10.1016/0888-7543(90)90287-5

Linkage of the multiple endocrine neoplasia type 2B gene (MEN2B) to chromosome 10 markers linked to MEN2A

Robert A. Norum, Ronald G. Lafreniere, Lawrence W. O'Neal, Thomas F. Nikolai, J. P. Delaney, James C. Sisson, Hagay Sobol, Gilbert M. Lenoir, Bruce A.J. Ponder, Huntington F. Willard, Charles E. Jackson

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Abstract

The syndrome of multiple endocrine neoplasia type 2B (MEN 2B) resembles that of MEN 2A in that both include medullary carcinoma of the thyroid, pheochromocytoma, and autosomal dominant inheritance, but is distinct in that MEN 2B patients have neuromas of the mucous membranes. MEN2A has been linked to RBP3, D10S5, FNRB, D10S15, and D10Z1 near the centromere of chromosome 10. We examined linkage between MEN2B and RFLPs on chromosome 10 in all available members in two or three generations of 14 kindreds. The centromere marker D10Z1 was linked to MEN2B with a peak lod score of 5.42 at θ = 0.02. One possible recombinant was observed between D10Z1 and MEN2B. Multipoint analysis of RFLPs at FNRB, D10Z1, RBP3, and D10S15 gave a peak lod score of 7.12 at the midpoint between D10Z1 and RBP3 on the long arm (band q11). The most likely gene order FNRB-D10Z1-MEN2B was 27 times more likely than MEN2B-FNRB-D10Z1 and 3 1 2 times more likely than FNRB-MEN2B-D10Z1. Additional data will be required to establish the order of these loci with confidence.

Original language	English (US)
Pages (from-to)	313-317
Number of pages	5
Journal	Genomics
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(90)90287-5
State	Published - Oct 1990
Externally published	Yes

Bibliographical note

Funding Information:
was sponsored in part by the Dykstra departemental de 1’Ain of the Ligue le Cancer, and by National Institutes

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@article{62d6ae7aa928446fae53b33176c1368b,

title = "Linkage of the multiple endocrine neoplasia type 2B gene (MEN2B) to chromosome 10 markers linked to MEN2A",

abstract = "The syndrome of multiple endocrine neoplasia type 2B (MEN 2B) resembles that of MEN 2A in that both include medullary carcinoma of the thyroid, pheochromocytoma, and autosomal dominant inheritance, but is distinct in that MEN 2B patients have neuromas of the mucous membranes. MEN2A has been linked to RBP3, D10S5, FNRB, D10S15, and D10Z1 near the centromere of chromosome 10. We examined linkage between MEN2B and RFLPs on chromosome 10 in all available members in two or three generations of 14 kindreds. The centromere marker D10Z1 was linked to MEN2B with a peak lod score of 5.42 at θ = 0.02. One possible recombinant was observed between D10Z1 and MEN2B. Multipoint analysis of RFLPs at FNRB, D10Z1, RBP3, and D10S15 gave a peak lod score of 7.12 at the midpoint between D10Z1 and RBP3 on the long arm (band q11). The most likely gene order FNRB-D10Z1-MEN2B was 27 times more likely than MEN2B-FNRB-D10Z1 and 3 1 2 times more likely than FNRB-MEN2B-D10Z1. Additional data will be required to establish the order of these loci with confidence.",

author = "Norum, {Robert A.} and Lafreniere, {Ronald G.} and O'Neal, {Lawrence W.} and Nikolai, {Thomas F.} and Delaney, {J. P.} and Sisson, {James C.} and Hagay Sobol and Lenoir, {Gilbert M.} and Ponder, {Bruce A.J.} and Willard, {Huntington F.} and Jackson, {Charles E.}",

note = "Funding Information: was sponsored in part by the Dykstra departemental de 1{\textquoteright}Ain of the Ligue le Cancer, and by National Institutes",

year = "1990",

month = oct,

doi = "10.1016/0888-7543(90)90287-5",

language = "English (US)",

volume = "8",

pages = "313--317",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Linkage of the multiple endocrine neoplasia type 2B gene (MEN2B) to chromosome 10 markers linked to MEN2A

AU - Norum, Robert A.

AU - Lafreniere, Ronald G.

AU - O'Neal, Lawrence W.

AU - Nikolai, Thomas F.

AU - Delaney, J. P.

AU - Sisson, James C.

AU - Sobol, Hagay

AU - Lenoir, Gilbert M.

AU - Ponder, Bruce A.J.

AU - Willard, Huntington F.

AU - Jackson, Charles E.

N1 - Funding Information: was sponsored in part by the Dykstra departemental de 1’Ain of the Ligue le Cancer, and by National Institutes

PY - 1990/10

Y1 - 1990/10

N2 - The syndrome of multiple endocrine neoplasia type 2B (MEN 2B) resembles that of MEN 2A in that both include medullary carcinoma of the thyroid, pheochromocytoma, and autosomal dominant inheritance, but is distinct in that MEN 2B patients have neuromas of the mucous membranes. MEN2A has been linked to RBP3, D10S5, FNRB, D10S15, and D10Z1 near the centromere of chromosome 10. We examined linkage between MEN2B and RFLPs on chromosome 10 in all available members in two or three generations of 14 kindreds. The centromere marker D10Z1 was linked to MEN2B with a peak lod score of 5.42 at θ = 0.02. One possible recombinant was observed between D10Z1 and MEN2B. Multipoint analysis of RFLPs at FNRB, D10Z1, RBP3, and D10S15 gave a peak lod score of 7.12 at the midpoint between D10Z1 and RBP3 on the long arm (band q11). The most likely gene order FNRB-D10Z1-MEN2B was 27 times more likely than MEN2B-FNRB-D10Z1 and 3 1 2 times more likely than FNRB-MEN2B-D10Z1. Additional data will be required to establish the order of these loci with confidence.

AB - The syndrome of multiple endocrine neoplasia type 2B (MEN 2B) resembles that of MEN 2A in that both include medullary carcinoma of the thyroid, pheochromocytoma, and autosomal dominant inheritance, but is distinct in that MEN 2B patients have neuromas of the mucous membranes. MEN2A has been linked to RBP3, D10S5, FNRB, D10S15, and D10Z1 near the centromere of chromosome 10. We examined linkage between MEN2B and RFLPs on chromosome 10 in all available members in two or three generations of 14 kindreds. The centromere marker D10Z1 was linked to MEN2B with a peak lod score of 5.42 at θ = 0.02. One possible recombinant was observed between D10Z1 and MEN2B. Multipoint analysis of RFLPs at FNRB, D10Z1, RBP3, and D10S15 gave a peak lod score of 7.12 at the midpoint between D10Z1 and RBP3 on the long arm (band q11). The most likely gene order FNRB-D10Z1-MEN2B was 27 times more likely than MEN2B-FNRB-D10Z1 and 3 1 2 times more likely than FNRB-MEN2B-D10Z1. Additional data will be required to establish the order of these loci with confidence.

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U2 - 10.1016/0888-7543(90)90287-5

DO - 10.1016/0888-7543(90)90287-5

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SN - 0888-7543

VL - 8

SP - 313

EP - 317

JO - Genomics

JF - Genomics

IS - 2

ER -

Linkage of the multiple endocrine neoplasia type 2B gene (MEN2B) to chromosome 10 markers linked to MEN2A

Abstract

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