Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1

Cheryl A. Gale, Catherine M. Bendel, Mark McClellan, Melinda Hauser, Jeffrey M. Becker, Judith Berman, Margaret K. Hostetter

Research output: Contribution to journalArticlepeer-review

289 Scopus citations

Abstract

Adhesion and the ability to form filaments are thought to contribute to the pathogenicity of Candida albicans, the leading cause of fungal disease in immunocompromised patients. Int1p is a C. albicans surface protein with limited similarly to vertebrate integrins. INT1 expression in Saccharomyces cerevisiae was sufficient to direct the adhesion on of this normally nonadherent yeast to human epithelial cells. Furthermore, disruption of INT1 in C. albicans suppressed hyphal growth, adhesion to epithelial cells, and virulence in mice. Thus, INT1 links adhesion, filamentous growth, and pathogenicity in C. albicans and Int1p may be an attractive target for the development of antifungal therapies.

Original languageEnglish (US)
Pages (from-to)1355-1358
Number of pages4
JournalScience
Volume279
Issue number5355
DOIs
StatePublished - Feb 27 1998

Fingerprint Dive into the research topics of 'Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1'. Together they form a unique fingerprint.

Cite this