Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes

M. C. Carroll, P. Katzman, E. M. Alicot, B. H. Koller, D. E. Geraghty, H. T. Orr, J. L. Strominger, T. Spies

Research output: Contribution to journalArticlepeer-review

289 Scopus citations

Abstract

The tumor necrosis factor (TNF) α and β gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.

Original languageEnglish (US)
Pages (from-to)8535-8539
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume84
Issue number23
DOIs
StatePublished - 1987

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