The NLRP3 inflammasome: Physiopathology and therapeutic application

Thomas Gicquel; Sacha Robert; Tatiana Victoni; Vincent Lagente

doi:10.1016/j.lpm.2016.01.006

The NLRP3 inflammasome: Physiopathology and therapeutic application

Thomas Gicquel, Sacha Robert, Tatiana Victoni, Vincent Lagente

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

The innate immune system constitutes the first line of host defense against pathogens. “Nonself”, such as exogenous particles or pathogens, triggers an inflammatory response. Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as IL-1β. Activation of the NLRP3 inflammasome pathway, the most extensively studied, appears to be the corner stone of many inflammatory diseases, including Crohn's disease, rheumatoid arthritis and gout. Cryopyrine-associated periodic syndromes (CAPS) are NLRP3 inflammasome-associated diseases. Canakinumab (Ilaris^®) is the only drug approved for CAPS treatment in France. Targeted therapy against NLRP3 inflammasome and IL-1β might be the new anti-inflammatory drugs.

Original language	English (US)
Pages (from-to)	438-446
Number of pages	9
Journal	Presse Medicale
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/j.lpm.2016.01.006
State	Published - Apr 1 2016
Externally published	Yes

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© 2016 Elsevier Masson SAS

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abstract = "The innate immune system constitutes the first line of host defense against pathogens. “Nonself”, such as exogenous particles or pathogens, triggers an inflammatory response. Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as IL-1β. Activation of the NLRP3 inflammasome pathway, the most extensively studied, appears to be the corner stone of many inflammatory diseases, including Crohn's disease, rheumatoid arthritis and gout. Cryopyrine-associated periodic syndromes (CAPS) are NLRP3 inflammasome-associated diseases. Canakinumab (Ilaris{\textregistered}) is the only drug approved for CAPS treatment in France. Targeted therapy against NLRP3 inflammasome and IL-1β might be the new anti-inflammatory drugs.",

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AU - Gicquel, Thomas

AU - Robert, Sacha

AU - Victoni, Tatiana

AU - Lagente, Vincent

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N2 - The innate immune system constitutes the first line of host defense against pathogens. “Nonself”, such as exogenous particles or pathogens, triggers an inflammatory response. Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as IL-1β. Activation of the NLRP3 inflammasome pathway, the most extensively studied, appears to be the corner stone of many inflammatory diseases, including Crohn's disease, rheumatoid arthritis and gout. Cryopyrine-associated periodic syndromes (CAPS) are NLRP3 inflammasome-associated diseases. Canakinumab (Ilaris®) is the only drug approved for CAPS treatment in France. Targeted therapy against NLRP3 inflammasome and IL-1β might be the new anti-inflammatory drugs.

AB - The innate immune system constitutes the first line of host defense against pathogens. “Nonself”, such as exogenous particles or pathogens, triggers an inflammatory response. Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as IL-1β. Activation of the NLRP3 inflammasome pathway, the most extensively studied, appears to be the corner stone of many inflammatory diseases, including Crohn's disease, rheumatoid arthritis and gout. Cryopyrine-associated periodic syndromes (CAPS) are NLRP3 inflammasome-associated diseases. Canakinumab (Ilaris®) is the only drug approved for CAPS treatment in France. Targeted therapy against NLRP3 inflammasome and IL-1β might be the new anti-inflammatory drugs.

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The NLRP3 inflammasome: Physiopathology and therapeutic application

Abstract

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