Linezolid-associated toxic optic neuropathy

J. C. Rucker, S. R. Hamilton, D. Bardenstein, C. M. Isada, M. S. Lee

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81 Scopus citations


The oxazolidinone antimicrobial linezolid is effective against grampositive bacteria. Although maximal recommended therapy is 28 days, treatment durations greater than this are common. Linezolid may cause reversible optic neuropathy and irreversible peripheral neuropathy after months of treatment. Three cases of linezolid-induced optic and peripheral neuropathy are described, and previously reported cases of linezolid-induced optic neuropathy are reviewed. The mechanism of neural toxicity may be impairment of mitochondrial protein synthesis.

Original languageEnglish (US)
Pages (from-to)595-598
Number of pages4
Issue number4
StatePublished - Feb 2006

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    Rucker, J. C., Hamilton, S. R., Bardenstein, D., Isada, C. M., & Lee, M. S. (2006). Linezolid-associated toxic optic neuropathy. Neurology, 66(4), 595-598.