## Abstract

Reversed-phase liquid chromatographic capacity factors are well correlated by an equation of the form: {Mathematical expression} where mV/100 measures the cavity term and π^{*}, β, and α are the solvatochromic parameters that measure solute dipolarity/polarizability, hydrogen bond acceptor basicity, and hydrogen bond donor acidity respectively. Liquid molar volume (molecular weight divided by liquid density at 20°C) {Mathematical expression}, and computer-calculated intrinsic (van der Waals) molecular volume, {Mathematical expression}, are compared as measures of the cavity term in a number of correlations. {Mathematical expression} leads to more precise correlations as well as to a "cleaner" dissection of the multiple solute/solvent interactions. The opposing exoergic effect of solvent donor/solute acceptor hydrogen bonding, and endoergic cavity term are the main factors influencing HPLC capacity factors.

Original language | English (US) |
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Pages (from-to) | 473-477 |

Number of pages | 5 |

Journal | Chromatographia |

Volume | 21 |

Issue number | 8 |

DOIs | |

State | Published - Aug 1 1986 |

## Keywords

- Cavity term
- Column liquid chromatography
- Molar volumes
- Reversed-phase capacity factors