Ligand topology tuning of iron-catalyzed hydrocarbon oxidations

Miquel Costas, Lawrence Que

Research output: Contribution to journalArticlepeer-review

158 Scopus citations


Quite unexpectedly, the topology of the tetradentate ligand in [FeII-(bpmcn)(OTf)2] (bpmcn = N,N′- bis-(2-pyridylmethyl)-N,N′-dimethyl-trans-1,2-diaminocyclohexane), whether cis-α or cis-β (see picture), determines the course of catalytic alkane hydroxylation and olefin oxidation reactions with H2O2, which afford products with varying stereo-selectivity and dramatically different sources of incorporated oxygen. These results demonstrate the exquisite role ligands can play in the fine tuning of the reactivity of an iron catalyst.

Original languageEnglish (US)
Pages (from-to)2179-2181
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number12
StatePublished - Jun 17 2002


  • Homogeneous catalysis
  • Iron
  • Ligand effects
  • Oxidation
  • Reaction mechanisms


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