Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In

Research output: Contribution to journalShort surveypeer-review

5 Scopus citations

Abstract

CNS angiogenesis and blood-brain barrier integrity are controlled by the canonical Wnt pathway. In this issue of Neuron, Cho et al. (2017) use advanced mouse genetics and biochemical experiments to unravel the ligand-specific association of membrane proteins GPR124 and RECK with Wnt receptor complexes.

Original languageEnglish (US)
Pages (from-to)983-985
Number of pages3
JournalNeuron
Volume95
Issue number5
DOIs
StatePublished - Aug 30 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.

Keywords

  • Gpr124
  • Reck
  • Wnt7
  • angiogenesis
  • blood-brain barrier
  • co-activator
  • ligand specificity
  • receptor complex

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