Lifestyle and colon cancer: An assessment of factors associated with risk

Martha L. Slatlery, Sandra L. Edwards, Kenneth M. Boucher, Kristin Anderson, Bette J. Caan

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Studies of the etiology of colon cancer indicate that it is strongly associated with diet and lifestyle factors. The authors use data from a population-based study conducted in northern California, Utah, and Minnesota in 1991-1995 to determine lifestyle patterns and their association with colon cancer. Data obtained from 1,993 cases and 2,410 controls were grouped by using factor analyses to describe various aspects of lifestyle patterns. The first five lifestyle patterns for both men and women loaded heavily on dietary variables and were labeled: 'Western,' 'moderation,' 'calcium/low-fat dairy' 'meat and mutagens,' and 'nibblers, smoking, and coffee.' Other important lifestyle patterns that emerged were labeled 'body size,' 'medication and supplementation,' 'alcohol,' and 'physical activity.' Among both men and women, the lifestyle characterized by high levels of physical activity was the most marked lifestyle associated with colon cancer (odds ratios = 0.42, 95% confidence interval: 0.32, 0.55 and odds ratio = 0.52, 95% confidence interval: 0.39, 0.69, for men and women, respectively) followed by medication and supplementation (odds ratio = 1.68, 95% confidence interval: 1.29, 2.18 and odds ratio = 1.63, 95% CI 1.23, 2.16, respectively). Other lifestyles that were associated with colon cancer were the Western lifestyle, the lifestyle characterized by large body size, and the one characterized by calcium and low-fat dairy. Different lifestyle patterns appear to have age- and tumor site-specific associations.

Original languageEnglish (US)
Pages (from-to)869-877
Number of pages9
JournalAmerican journal of epidemiology
Volume150
Issue number8
DOIs
StatePublished - Oct 15 1999

Bibliographical note

Funding Information:
This study was funded by grant RO1 CA48998 to Dr. Martha L. Slattery. Case identification and verification was supported by the Utah Cancer Registry, the Northern California Cancer Registry, the Sacramento Tumor Registry, and the Minnesota Cancer Surveillance System.

Keywords

  • Anti-inflammatory agents
  • Aspirin
  • Colonic neoplasms
  • Diet
  • Hormone replacement therapy
  • Nonsteroidal
  • Obesity
  • Physical exercise

Fingerprint Dive into the research topics of 'Lifestyle and colon cancer: An assessment of factors associated with risk'. Together they form a unique fingerprint.

Cite this