Life without myoglobin

D. J. Garry, A. Meeson, Z. Yan, R. S. Williams

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Hemoproteins are widely distributed among prokaryotes, unicellular eurokaryotes, plants and animals [1]. Myoglobin, a cytoplasmic hemoprotein that is restricted to cardiomyocytes and oxidative skeletal myofibers in vertebrates, has been proposed to facilitate oxygen transport to the mitochondria [1-3]. This cytoplasmic hemoprotein was the first protein to be subjected to definitive structural analysis and has been a subject of long-standing and ongoing interest to biologists [1-3]. Recently, we utilized gene disruption technology to generate mice that are viable and fertile despite a complete absence of myoglobin [4]. This unexpected result led us to reexamine existing paradigms regarding the function of myoglobin in striated muscle.

Original languageEnglish (US)
Pages (from-to)896-898
Number of pages3
JournalCellular and Molecular Life Sciences
Volume57
Issue number6
DOIs
StatePublished - Jan 1 2000

Keywords

  • Heart
  • Myoglobin
  • Oxygen transport
  • Skeletal muscle
  • Transgenic mice

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