Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region.

Peter J. Lynch

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


Lichen simplex chronicus (LSC) of the anogenital area is an eczematous disease characterized by unremitting itching and scratching. In most instances, it arises in individuals who are genetically atopic, and as such, LSC can be viewed as a localized variant of atopic/neurodermatitis. Common triggers for the development of the disease include psychological distress, and local environmental problems such as heat, sweating, and excess dryness. Lichen simplex chronicus may also develop as a superimposed condition in the presence of other anogenital diseases such as candidiasis, psoriasis, lichen sclerosus, tinea cruris, and neoplasia. Lichen simplex chronicus frequently persists as an itch-scratch cycle, even when environmental triggers are removed and the underlying disease is treated. For this reason, successful therapy requires attention not only to trigger factors, but also to repair of the damaged barrier layer, reduction in inflammation, and breakup of the itch-scratch cycle.

Original languageEnglish (US)
Pages (from-to)8-19
Number of pages12
JournalDermatologic therapy
Issue number1
StatePublished - 2004
Externally publishedYes


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