LFG: An anti-apoptotic gene that provides protection from Fas-mediated cell death

Nikunj V. Somia, Mark J. Schmitt, Douglas E. Vetter, Daniel Van Antwerp, Stephen F. Heinemann, Inder M. Verma

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


Programmed cell death regulates a number of biological phenomena, and the apoptotic signal must itself be tightly controlled to avoid inappropriate cell death. We established a genetic screen to search for molecules that inhibit the apoptotic signal from the Fas receptor. Here we report the isolation of a gene, LFG, that protects cells uniquely from Fas but not from the mechanistically related tumor necrosis factor α death signal. LFG is widely distributed, but remarkably is highly expressed in the hippocampus. LFG can bind to the Fas receptor, but does not regulate Fas expression or interfere with binding of an agonist antibody. Furthermore LFG does not inhibit binding of FADD to Fas.

Original languageEnglish (US)
Pages (from-to)12667-12672
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number22
StatePublished - Oct 26 1999


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